The diffractive program of the CDF Collaboration at the Fermilab Tevatron p anti-p Collider is reviewed with emphasis on recent results from Run-II and future prospects. Diffractive p anti-p interactions are characterized by the presence of at least one large rapi+dity gap, defined as a region of pseudorapi+dity [1] devoid of particles. A diffractive rapi+dity gap, which may be forward (adjacent to a leading nucleon) or central, is presumed to be formed by the exchange of a Pomeron [2], which in QCD is a color singlet quark/gluon object with vacuum quantum numbers. Diffraction in which there is a high momentum-transfer partonic scattering in the event in addition to the rapi+dity gap is referred to an hard diffraction. In this paper, we briefly review the results on diffraction obtained by the Collider Detector at Fermilab (CDF) in Run-I (1992-1995), present an update of results from Run-II, which is in progress, and discuss future prospects.