Measurements of charm and beauty production at the Tevatron have historically shown hints of disagreement when compared to Next to Leading Order predictions. In this review four measurements performed with recent p anti-p collision data at s**(1/2) = 1.96 TeV by the CDF and D0 collaborations are presented: inclusive muon production; inclusive beauty (b) quark production; the production of b anti-b quarks; the production of beauty and charm quarks in association with a high energy photon. In all cases measurements are in agreement with theoretical prediction.