The CDF Run II silicon detector with its 8 layers of double- and single-sided silicon microstrip sensors and a total 722,432 readout channels is one of the largest silicon detector devices currently in use by a HEP experiment. We report our experience commissioning and operating this complex device during the first 4 years of Run II. As the luminosity delivered by the Tevatron increases, we have observed measurable effects of radiation damage in studies of charge collection and noise versus applied bias voltage at many different integrated luminosities. We discuss these studies and their impact on the expected lifetime of the detector.