After an introduction on the peculiarities of flavor-physics measurements at a hadron collider, and on the upgraded Collider Detector at Fermilab (CDF II), I show recent results on two-body B0 and B0(s) decays into charged, pseudo-scalar, charmless mesons or into muons, to illustrate how the flavor physics program at CDF is competitive with (in B0 decays) and complementary (in B0(s) decays) to B-factories. Results shown include the new measurement of the CP-violating asymmetry in B0 --> K+ pi+- decays, the first measurement of the time-evolution of B0(s) --> K+ K- decays, and the world best limits on the decay rates of rare B0_(s) --> mu+ mu- modes.