Search for single top production at CDF We present recent results from searches for single top quark production in the 1 fb$^{-1}$ dataset accumulated with the CDF II detector. In the 1.96 TeV p-pbar collisions at the Tevatron, individual top quarks are expected to be produced in association with bottom quarks mainly through the exchange of an off-shell W boson ($s$-channel), or the W-gluon fusion process ($t$-channel). Such events (as of this writing) have yet to be observed. We select events with one charged lepton, high missing transverse energy, and at least 2 jets, one of which is identified as a b-quark using the CDF Silicon detector. Distinguishing the single top signal from significant backgrounds from W+jets processes with heavy flavour such as Wbb, Wcc, Wc proves extremely challenging. We present combined searches for the $s$- and $t$- channels, along with individual searches for each channel, using several powerful multivariate techniques, which together provide us with unprecedented sensitivity and potential for first observation of single top production.