We report preliminar results on the measurement of the isolated prompt photon cross section as a function of photon transverse momentum $p^\gamma_T$ at the Tevatron using 3 fb${}^{-1}$ of data collected by the CDF experiment in Run II. The measurements are performed for photons with $p^\gamma_T$ above 30~GeV/$c$ and rapidity in the region $|\eta^{\gamma}| < 1$. The measurements are compared to next-to-leading order perturbative QCD predictions.