Dear Collaborators, I am posting my PhD thesis in the CDF Note database. The title is ``Observation of Diffractive Bottom Quark Production in 1.8-TeV Proton-Antiproton Collisions''. The Abstract reads as follows: The bottom quark production in the single diffractive dissociation is first observed in $p\bar{p}$ collisions at $\sqrt{s}$=1.8 TeV using the Collider Detector at Fermilab. The absence of an energy flow in the forward rapidity region (`rapidity gap') is used as an evidence of the single diffraction. The high-$p_T$ electron in the $E_T$ range of 9.5 $